A Serial Rapist continues the story of A Class Reunion, and proves the innocence of Horace Hastings, the accused rapist and murderer in that story, who was killed before a trial was held. After a series of new rapes and murders are reported up and down the East Coast from Sussex County Delaware area to several southern states, Special FBI Agent Robert Spedden reopens the old cases and tracks the new suspect Fred Messick to Tampa, Florida where a trap is setup to capture him.