The worldwide use of psychoactive substances remains a major public health problem. It has spread in an unusual way in recent times. The methodology of this book was based on taking information from its source, where a sample of consumers of psychoactive substances (hallucinogens). The patient profile is characterized by their young age (48%), young adults [21-25 years], male predominance (82%), versus (18%) females. Pregabalin(R) was the most commonly used substance (59%), followed by Tramadol(R) (18%). The distribution of patients according to daily dose shows a high rate of 2 doses per day (35%), with an age of consumption of more than 5 years, central nervous system disorders (33%) and other disorders. Management is marked by the presence of a relatively good treatment protocol in the department, despite the absence of excellent conditions for treatment, and drug testing.