This book gives an extensive overview on the pathogenesis and diagnosis of Alzheimer's disease. Over 6 million Europeans, out of which more than a quarter of people who are over the age of 85 and 10% who are over the age of 65, have been affected by Alzheimer's Dementia (AD). Given the steady aging of European societies, cognitive decline and dementia have grown into a crucial health problem with a great socioeconomic effect on patients, their caregivers and families, society, and national health care policy. The amount of people with dementia is estimated to double by 2030 and further increase by 2050. There is a critical requirement for creative methods to boost understanding of pathological events that would transform into the establishment of successful prevention or new treatment techniques. Advancements in comprehending pathological events in AD have been achievable by employing cell cultures, genetically modified organisms and animal models that do not have the complexity of events happening in humans. It is necessary that we conquer this restraint as well by using data from humans - for analyzing pathological pathways in AD in a multidisciplinary setting.