Interceptive orthodontics is employed to recognize and eliminate potential irregularities and malposition in the developing dentofacial complex. These procedures are directed to lessen or to eliminate the severity of developing malocclusion. The early assessment of the child, followed by regular review, and treatment at the appropriate time if necessary, will do much to reduce malocclusion to the basic non-preventable level. The key to the prevention of this kind is awareness. This part examines the key areas relating to interceptive orthodontics with the available evidence to support the clinical management of common problems presenting in the mixed dentition.