When do people greet each other on WhatsApp? How do people start chats on Tinder? How are emotions displayed in video-mediated workplace interaction? How do people converse with a social robot? This volume offers a state-of-the-art collection of articles dealing with digital interaction in different settings - mobile messaging, social media, video conferencing, and human-computer interaction. It shows that while there are different applications and platforms that employ both written and spoken forms of interaction, the method of Conversation Analysis is a powerful tool for revealing the systematicity of varying linguistic and multimodal resources and practices specific to each context and platform. The volume offers in-depth analyses of interactional practices in different platforms; the languages covered by the chapters include Finnish, Dutch, German, and Hebrew. In addition, the volume offers a comprehensive introduction to the central concepts of Conversation Analysis and their applicability to digital interaction. In that way, the volume is suitable for all students and researchers interested in digital interaction and Conversation Analysis, also from the methodological perspective. It is also well suited as course material for university students.