In this issue of Hematology/Oncology Clinics , guest editors Drs. Nancy Berliner and Barbara A. Degar bring their considerable expertise to the topic of Hemophagocytic Syndromes . Top experts provide in-depth perspectives on these uncommon but potentially life-threatening disorders, including pathology of histiocytic disorders, genomic alterations in LCH, immunopathology of HLH, clinical characteristics and treatment of familial HLH, and much more.