The book explores the available omics resources, the integration of multi-omics data, and systems biology methods, focusing on their applications in cereals breeding and research. It highlights current and innovative strategies to understand complex traits, to improve yield, and to enhance resistance to biotic and abiotic stresses. It also addresses the challenges and opportunities associated with modeling multi-omics data and analyzing systems-level information. By leveraging systems biology and integrated omics research, this book aims to redefine the future research agenda for cereal improvement.