This publication provides detailed guidelines for the safety assessment of nuclear power structures against mechanical impact, explosion and fire caused by human induced external events. It covers the characterization of loading, the assessment of structural integrity using both simplified methods and more elaborated methodologies, and the assessment of induced vibration. The acceptance criteria provided in the publication are for different failure modes: overall stability, overall bending and shear, local failure modes and induced vibrations. The process of analyzing fire consequences is also included.