A Briefe Discovrse of a Disease called the Suffocation of the Mother is a fascinating medical treatise first published in 1602 by Edward Jorden, a prominent English physician. This early modern work explores the mysterious and often misunderstood condition known as the suffocation of the mother, now recognized as hysteria or a range of psychosomatic disorders primarily affecting women. Jorden’s treatise is notable for its attempt to demystify the symptoms and causes of this affliction, which was frequently attributed to supernatural forces such as witchcraft or demonic possession in the early seventeenth century. Drawing on classical sources, contemporary medical knowledge, and his own clinical observations, Jorden argues that the disease arises from natural causes, specifically disorders of the womb and the imbalance of bodily humors. He meticulously describes the symptoms—such as choking sensations, convulsions, and fits—and distinguishes them from those caused by supposed witchcraft, thus challenging prevailing superstitions and the persecution of women accused of witchcraft. Jorden’s work is both a medical text and a social commentary, advocating for a more rational and compassionate approach to women’s health. A Briefe Discovrse of a Disease called the Suffocation of the Mother is a landmark in the history of medicine and gender studies, offering insight into early modern attitudes toward women’s bodies, mental health, and the intersection of science and superstition. It remains a valuable resource for historians, scholars of gender and medicine, and anyone interested in the evolution of medical thought.