This important and influential speech, delivered by Manasseh Cutler in 1814, offers a compelling perspective on the development of the American Midwest in the early 19th century, and the challenges and opportunities that lay ahead. Cutler, a prominent scientist, educator, and statesman, was a key figure in the settlement and development of the Ohio Valley, and this discourse reflects his deep knowledge, insight, and vision for the region. With its powerful language, inspiring tone, and enduring relevance, this discourse remains a classic of American history and a must-read for anyone interested in the development of the American Midwest. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.