In "A Little Girl in Old St. Louis," the story is set in the early days of St. Louis, capturing the life and adventures of a young girl during this period. The novel likely explores the historical and cultural backdrop of St. Louis in the 18th or early 19th century, highlighting the challenges and experiences of growing up in a developing frontier town.The protagonist, a young girl, probably navigates through various adventures, family dynamics, and social changes, providing readers with a glimpse into the daily life and historical context of the time. Themes of resilience, friendship, and personal growth are common in Douglas's works and are likely present in this novel as well.