This volume constitutes selected and revised papers of the 5th International Conference on Advanced Informatics for Computing Research, ICAICR 2021, held in Gurugram, India, in December 2021.  The 17 revised full papers and 6 short papers presented were carefully reviewed and selected from 306 submissions. The papers targeted state-of-the-art as well as emerging topics pertaining to advanced informatics for computing research and its implementation for engineering applications.