Rome, Italy. The scene of a mass breakout of convicted felons in this seventh, and final instalment of the Agents Amiss series. Who better to call, of course, than the dynamic duo of Agent 314 and Agent 999? Supported by Secret Agent 23 and Agent 47, the quartet must hunt down and catch a group of known villains, led by Timothy Toad, an antagonist they know well from their experiences in Greece. Aided, as well, by gifts from Inventor 13, our protagonists must move fast and catch these murderous villains as they run riot down the Roman streets. In a completely different and challenging new set of circumstances than they are used to, can Agents 314 and 999 save the day once more, or will the world go mad as the Eternal Evildoers leave chaos and despair in their wake?