This book constitutes the proceedings of the 17th International Conference on Agents and Artificial Intelligence, ICAART 2025, which took place in Porto, Portugal, during February 23&25, 2025. The 52 full papers and 39 short papers presented in these two volumes were carefully reviewed and selected from 472 submissions. The papers are organized in the following topical sections of relevant trends of current research on Agents and Artificial Intelligence, including: Machine Learning, Deep Learning, Multi-Agent Systems, Natural Language Processing, AI and Creativity, Intelligence and Cybersecurity, Explainable AI, Industrial Applications of AI, Simulation and Agent Models and Architectures.