This volume convenes selected, peer-reviewed research and survey articles that address the modern state-of-the-art in varied areas of applied mathematical analysis. They primarily include presentations as well as invited contributions for the 1st Southern Georgia Mathematics Conference (SGMC) that was virtually held on April 2-3, 2021 at the Georgia Southern University, Statesboro, USA. Papers in this volume incorporate both advanced theory and methods from mathematical analysis, and cover myriad topics like imaging and inverse problems, evolutionary PDEs, symbolic computation, dynamics and data analysis, data science, computational mathematics, and more. This first volume focuses on mathematical analysis theory and applications.   These studies and findings contained herein will be of interest to researchers and graduate students working in the fields of mathematical analysis, modeling, data analysis and computation, with applications in many interdisciplinary applied sciences, as in statistics, physics, biology, and medical imaging. They are particularly relevant to those at the forefront of applied mathematical and statistical analysis, as well as data science and other computational science disciplines.   In its first edition, the Southern Georgia Mathematics Conference brought together 74 speakers from 70 different institutions, from the USA, Canada, Austria, and Botswana. Attendees included faculty, researchers, experts, graduate and undergraduate students from all over the world.