This book constitutes the proceedings from the workshops BRIDGE+DeCaF 2025, held at the 28th International conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2025, which took place in Daejeon, South Korea in September 2025. The 16 papers presented in this volume were carefully reviewed and selected from the total submissions from the following workshops: First International Workshop on Bridging Regulatory Science and Medical Imaging Evaluation (BRIDGE 2025) 6th MICCAI Workshop on Distributed, Collaborative and Federated Learning (DeCaF 2025)