In an age marked by rapid globalization, technological disruption, and cultural flux, leadership demands more than technical skill — it requires cultural intelligence, empathy, and transdisciplinary vision. The Proceedings of the Fourth National Transdisciplinary Conference on Cultural Intelligence & Global Leadership (CIGL 2025), hosted by Inspiria Knowledge Campus, brings together scholars, practitioners, and innovators across management, media, hospitality, finance, design, technology, and the social sciences. This collection showcases groundbreaking research and lived insights on how cultural intelligence shapes tourism, entrepreneurship, financial systems, digital communication, wellness, and global leadership. From exploring user-generated content in tourism and the ethics of cultural appropriation in branding, to examining the future of AI in communication, inclusive financial models, and sports as a site of leadership, the chapters illuminate how cultural intelligence offers both a compass and a bridge — guiding individuals, organizations, and communities in an interconnected world. Rich in diversity yet united by a common mission, this volume demonstrates that leadership today must be ethical, humane, and collaborative. It is an essential resource for academics, students, policymakers, and professionals seeking to understand how culture and intelligence intersect to build sustainable futures.