Equate Medicated Callus Removers removes painful calluses. Cushion helps to relieve painful shoe pressure and friction. DIRECTIONS: Wash affected area and dry thoroughly. If necessary, cut medicated patch to fit callus. Apply by pressing adhesive side of medicated patch onto callus. Cover patch with cushion. Remove patch after 2 days. Repeat procedure every 48 hours as needed (until callus is removed) for up to 14 days. To assist in callus removal at the end of the treatment period, soak in warm water for 5 minutes.