The story is set against the backdrop of the Wars of the Roses, a series of civil wars for the throne of England between the houses of Lancaster and York during the 15th century. The narrative follows the character Grisell Rutherford, known as "Grisly Grisell," and her experiences amidst the turmoil and conflicts of that era.Charlotte M. Yonge often incorporated historical events into her stories, providing readers with insights into different periods of English history. "Grisly Grisell" is an example of Yonge's historical fiction, portraying the struggles, alliances, and intrigues of the Wars of the Roses while focusing on the life and adventures of its protagonist.