With more than twenty antiseizure medications (ASMs) available for clinical use it can be difficult to choose which ASM is the best option for each patient. This handbook explores the mechanisms of action, recommended doses, drug interactions, and most common side effects of each ASM currently available. It also includes a section with clinical pearls highlighting key points selected by experienced epileptologists. This handbook serves as a practical text to residents, fellows, and neurologists who treat patients with epilepsy.