SECTION III Methods. 21.The Humane Care and Use of Laboratory Animals in Toxicology Research.22. Novel Approaches and Alternative Models. Validation and Regulatory Acceptance of Toxicological Testing Methods and Strategies.23.Modern Instrumental Methods for Studying Mechanisms of Toxicology. 24.Acute Toxicity and Eye Irritancy. 25. Short-Term, Subchronic, and Chronic Toxicology Studies. 26.Genetic and Epigenetic Toxicology. 27.Carcinogenicity Bioassays and Related Assays; Human Relevance. 28.Assessment of Behavioral Toxicity. SECTION IV Organ- and System-Specific Toxicology. 29.Dermatotoxicology. 30.Inhalation Toxicology. 31.Gastrointestinal Toxicology. 32. ãHepatotoxicology. 33.Principles and Methods for Renal Toxicology. 34.Cardiovascular Toxicology Methods. 35.Neurotoxicology.36.Toxicology of the Endocrine System. 37.Assessment of Male Reproductive Toxicity. 38.Female Reproductive and Developmental Toxicology. 39.Immunotoxicology. The Immune System Response to Toxic Insult.