In this issue of Urologic Clinics of North America , guest editor Dr. Peter E. Clark brings his considerable expertise to the topic of Invasive Bladder Cancer . Invasive bladder cancer remains a challenging disease to manage, and in this issue, top experts focus on the latest advancements in management, including cystectomy, optimizing surgical care, novel approaches to systemic therapy, bladder-sparing approaches for the well-selected patient, and more.