This book constitutes the refereed proceedings of the 10th International Workshop on Learning Technology for Education Challenges, LTEC 2022, held in Hagen, Germany, in July 2022.  The 14 revised full papers and 6 short papers presented were carefully reviewed and selected from 41 submissions. The papers are organized in the following topical sections: learning methodologies and pandemic impact; learning practices and methodologies; learning technologies; learning technologies performance; serious games and virtual learning environments.