Unsuccessfully trying to repress the memory of a horrible event in her past, Gale realizes that her current life has become unbearable and agrees to take a chance on an untested treatment that has just become available, even though there are profound and unknown risks. Treatment for Gale is directed at erasing her unwanted memory, but unforeseen complications occur, including confabulation, which leads to abrupt changes and new challenges. Fortunately for Gale, she has friends who are there to help her: Jeff, a fellow graduate student, who is in love with her and will do absolutely anything for her, Peters, a relentless and ruthless detective who refuses to abandon her case, and Sibyl, her funny and sarcastic roommate.