Morton's Neuroma: The complete textbook for medical professionals. It includes, Aetiology of the condition, differental diagnosis, management options and treatment. The result of ultrasound guided injection has been included. Chapter of Histology has been added. Morton's neuroma is a painful foot condition that affects one of the nerves between the toes. It's also known as Morton's metatarsalgia or interdigital neuroma. In Morton's neuroma, a nerve in the foot becomes irritated and thickened, which can cause severe pain. The condition can occur in one foot or both feet. It usually affects the nerve between the third and fourth toes, but sometimes the second and third toes are affected. Morton's neuroma can occur at any age, but most often affects middle-aged women. This may be because women tend to wear tight or high-heeled shoes that can put pressure on the feet. It's also increasingly seen in runners, possibly because of the increased pressure on the toes that occurs when running.