This book gathers a selection of peer-reviewed papers presented at the International Conference on Operations Research (OR 2022), which was held at Karlsruhe Institute of Technology, Germany, on September 6-9, 2022. KIT's Institute for Operations Research (IOR) hosted the conference together with the Institute for Industrial Production (IIP), the Institute for Automation and Applied Informatics (IAI), and the Institute for Material Handling and Logistics (IFL). The respective papers discuss classical mathematical optimization, statistics and simulation techniques. These are complemented by computer science methods, and by tools for processing data, designing and implementing information systems. The book also examines recent advances in information technology, which allow big data volumes to be processed and enable real-time predictive and prescriptive business analytics to drive decisions and actions. Lastly, it includes problems modeled and treated while taking into account uncertainty, risk management, behavioral issues, etc.