The Patient-Centered Clinical Method (PCCM) has been a core tenet of the practice and teaching of medicine since the first edition of Patient-Centered Medicine - Transforming the Clinical Method was published in 1995. This timely fourth edition continues to define the principles underpinning the patient-centered clinical method using four major components, clarifying its evolution and consequent development, and it brings the reader fully up to date. It reinforces the relevance of the method in the current much-changed realities of health care in a world where virtual care will remain common, dependence on technology is rising, and societal changes away from compassion, equity, and relationships toward confrontation, inequity, and self-absorption. Fully revised by its highly experienced author team ensuring wide interest and written for those practising now and for the practitioners of the future, this new edition will be welcomed by a wide international audience comprising all health professionals from medicine, nursing, social work, occupational therapy, physical therapy, pharmacy, veterinary medicine, and other fields.