In this issue of Infectious Disease Clinics of North America , guest editors Drs. Keith S. Kaye and Sorabh Dhar bring their considerable expertise to the topic of Infection Prevention and Control in Healthcare, Part 2 . In the next five years, it is anticipated that healthcare facilities will continue to evolve by integrating advanced technologies and infrastructure improvements to strengthen IPC programs, adopting innovative solutions to monitor and control infections. In this Part Two issue, top experts provide state-of-the-art information to infectious disease clinicians on these innovations in preventing healthcare-associated infections.