This book constitutes selected papers of the Third International Conference on Data Science, Medicine and Bioinformatics, IDMB 2019, held in Nanning, China, in June 2019.  The 19 full papers and 1 short paper were carefully reviewed and selected from 93 submissions. The papers are organized according to the following topical sections: business data science: fintech, management, and analytics.- health and biological data science.- novel data science theory and applications.