It's the morning of Black Friday. A mysterious sickness has gripped the world and driven millions to madness. When the infected arrive, the uninfected must band together and fight. Patrick and Nate are among the guests at an inn on a backroad in north Alabama. Officer Fulci arrives in a harried state with an injured man and immediately sets up a roadblock to detain everyone that arrives at the inn. There's no communication beyond the inn because of a lack of cellular service. Despite being in constant contact with dispatch, Fulci suspiciously avoid sharing information. As smoke rises from the city in the distance, suspicion and fear grip the detainees. Storm clouds roll in and the crisis that Fulci was attempting to prevent comes for them. They must unite in a struggle to survive the clawing and gnashing onslaught. All but cut off and abandoned, the group navigates through the world and their differences as they desperately move to escape the mysterious infection that has driven people feral. Hard decisions, compromise, and sacrifice become the group's only means of escaping the rising Sickness.