Spinal cord injury is a catastrophic injury affecting all body functions and imposing significant life-long impairment. Advances in spinal cord injury rehabilitation are required to ensure optimal physical and psychological adjustments to its impacts, and make sure that quality of life and life expectancy improve. This Special Issue consisting of a collection of research papers fulfils a vital strategy for achieving improvements after spinal cord injury. The papers are innovative, and each paper proposes features that will result, it is hoped, in real advances in rehabilitation. The range of topics is broad, ranging from psychological to physiological approaches. For example, exploring cognitive reserve and its association to cognitive impairment, the benefits of electrical stimulation to mobility function and autonomic dysreflexia, machine learning for the early prediction of pressure ulcers and robot-assisted gait training, investigating activity-based therapy for mobility, function and quality of life, and studying hypnosis-enhanced cognitive behaviour therapy for pain in a ventilator-dependent patient. These are all outstanding contributions. The Editors hope you enjoy reading these outstanding contributions to spinal cord injury rehabilitation research.