The Low Lives is a first-hand account of Bo, a young man who slips into homelessness in San Francisco. The story follows his progression from his initial carefree days in Golden Gate Park through more dark and dangerous times in the notorious Tenderloin district. Bo teams up with Ronnie, a magnetic and unpredictable homeless man, who acts as Bo's guide through the gritty and drug-ridden underworld. They embark upon a quest to find the true meaning of freedom while living outside the rules of traditional society. After a series of misadventures, Bo and Ronnie find themselves moving toward a turbulent conclusion that changes everything they believe about their lives on the streets.