In this issue of Gastrointestinal Endoscopy Clinics of North America, guest editors Drs. D. Nageshwar Reddy and Rupjyoti Talukdar bring their considerable expertise to the topic of Updates in Pancreatic Endotherapy. Leaders in the field highlight the evolution of pancreatic endotherapy and its progression to current procedures, covering the techniques, utility, and evidence-based efficacy of these procedures in daily practice.