Urothelial carcinoma, also known as transitional cell carcinoma, is a type of cancer that affects the urothelial cells lining the urinary tract, including the bladder, ureters, and renal pelvis. It is the most common type of bladder cancer and can occur in other parts of the urinary system. Risk factors include smoking or chewing tobacco, industrial smoke, and a history of chronic bladder inflammation or infections. Males in old age are particularly vulnerable to this type of cancer. Symptoms of urothelial carcinoma may include blood in the urine, changes in urinary habits, such as increased frequency or urgency, pain during urination, or pelvic pain. Diagnosis typically involves a combination of imaging tests, such as CT scans or MRIs, and a biopsy of the affected tissue. Therapeutic intervention depends on the stage and location of the cancer but may include surgery, chemotherapy, radiation therapy, immunotherapy, or targeted therapy. The topics covered in this extensive book deal with the core subject of urothelial carcinoma. It aims to shed light on some of the unexplored aspects of this subject, and the recent researches in this field. The elaborated content of this book provides the readers with a thorough understanding of the subject.